It is also released from damaged cells at sites of vascular injury, serving as an autocrine and paracrine stimulus for recruiting additional platelets and stabilizing the hemostatic plug. A specific phosphatase, which is a different enzymatic activity…
The cell membrane contains proteins that transport ions and water-soluble molecules into or out of the cell.
Because light energy powers this reaction in… …process, ATP is degraded to adenosine diphosphate (ADP), a molecule with only two phosphate bonds. The simpler metabolites formed via catabolic reactions are often the building-block metabolites used in anabolic reactions to synthesize more complex molecules (e.g., starch, proteins, or lipids). It has two phosphate groups attached to the nucleoside. Upon release from the platelet, ADP stimulates other platelets to activate when it binds to the ADP receptor on the platelet membrane. * Adenosine diphosphate (ADP) We need energy to do any work. Adenosine-5′-diphosphate (ADP) plays a key role in platelet function (see Chapter 10).Although ADP is a weak platelet agonist, when it is secreted from the platelet dense granules where it is stored, ADP amplifies the platelet responses induced by other platelet agonists. Some molecules are able to freely diffuse across the membrane in a process known as simple diffusion.The transfer of phosphate groups from high-energy donors to low-energy acceptors by way of the ATP-ADP system. To recharge the molecule by adding the third phosphate group requires energy derived from the breakdown of foodstuffs, or substrates. As such, it only induces shape change and reversible aggregation in human platelets, whereas the secretion of platelet-dense granule constituents and the ensuing secondary aggregation that are sometimes observed after stimulation with ADP of normal platelet-rich plasma (PRP) are triggered by thromboxane (TX) AThe search for the platelet receptor(s) for ADP was hindered for many years by technical difficulties, such as, for example, the limited variety of labeled compounds available for binding studies and their breakdown by nucleotidases on the platelet membrane.It is now established that platelets express two receptors for ADP: the GThe effects of ADP and ATP on platelet function are modulated We use cookies to help provide and enhance our service and tailor content and ads.
an adenine attached to the ribose sugar.
Adenosine-5′-diphosphate (ADP) plays a key role in platelet function (see Chapter 10).
Other articles where Adenosine diphosphate is discussed: heterocyclic compound: Five- and six-membered rings with two or more heteroatoms: Adenosine monophosphate, diphosphate, and triphosphate (AMP, ADP, and ATP, respectively) are important participants in energy processes in the living cell. ADP binding to P2Y1 (~150 copies per platelet), which is coupled to the α subunits of GATP is an antagonist of P2Y1 and P2Y12, but an activator of P2X1, a ligand-gated ion channel, that causes rapid influx of CaADP is a platelet agonist that interacts with platelet purinergic P2 receptors, including P2YADP is stored in platelet dense granules and released upon platelet activation. Adenosine monophosphate, diphosphate, and triphosphate (AMP, ADP, and ATP, respectively) are important participants in energy processes in the living cell. Its nucleoside contains a purine base, i.e. Two pathways are available: (1) anaerobic glycolysis, or fermentation, which operates in the absence of… …the cell, is made from adenosine diphosphate (ADP) and inorganic phosphate (P…only in the presence of ADP or AMP and are inhibited by ATP. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Get kids back-to-school ready with Expedition: Learn! ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780123693679508235URL: https://www.sciencedirect.com/science/article/pii/B9780128134566000096URL: https://www.sciencedirect.com/science/article/pii/B9780123693679507886URL: https://www.sciencedirect.com/science/article/pii/B9780323357623001256URL: https://www.sciencedirect.com/science/article/pii/B9780128126158000041URL: https://www.sciencedirect.com/science/article/pii/B9780123878373000195URL: https://www.sciencedirect.com/science/article/pii/B9780123842602500101URL: https://www.sciencedirect.com/science/article/pii/B9780123693679507722Pathologic Basis of Veterinary Disease (Sixth Edition), 2017The Role of Platelets in the Pathophysiology of Atherosclerosis and Its ComplicationsMelanie McCabe White B.A., ... Michael P. Condry, in ScienceDirect ® is a registered trademark of Elsevier B.V. Each of the compounds is composed of the nucleotide base adenine linked to the sugar … Marco Cattaneo, in Platelets (Second Edition), 2007. …group to a molecule of adenosine diphosphate (ADP)—or to state it in chemical terms, by the phosphorylation of ADP.
This reaction requires a substantial input of energy, much of which is captured in the bond that links the added phosphate group to ADP. …split from the ATP molecule, adenosine diphosphate, or ADP, is formed and inorganic phosphate is released, along with energy.) For this, Adenosine diphosphate (ADP) helps our cells have energy to do everything they need to do.
It is often called the molecular unit of currency, because it can both hold and release energy when a cell requires it. ADP was one of the earliest identified platelet agonists, but ADP receptors were only identified much later.ADP is a key platelet agonist that functions by binding to G protein coupled receptors, P2Y1 and P2YADP is an important primary platelet agonist and also amplifies other primary responses following its secretion from platelet dense granules.
Adenosine triphosphate, or ATP, functions as a cell's main source of energy.
I Introduction.
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