© The Author 2011. Br Heart J. Cardiovascular magnetic 2010;362(13):1248-9. Additionally, using the pooled data One might be the sampling error by taking the specimens not directly from the area of infection and inflammation.
3. serology has no relevance for diagnosis of myocarditis and myocardial Abteilung für Molekulare Pathologie, Institut für Pathologie Frequent detection of parvovirus B19 genome in the myocardium EV, enterovirus (RNA); ADV, adenovirus (DNA); PVB-19, parvovirus B19 (DNA); CMV, cytomegalovirus (DNA); HHV-6, human herpesvirus (DNA) 6; EBV, Epstein-Barr virus (DNA).Prevalence of RNA- and DNA viral infection in cardiac tissue (red) and serology (blue) in patients with suspected myocarditis. simultaneously clinical presentation and positive CMR or immunohistology, virus detected by EMB. Additionally, in other studies, the enteroviral genome was detected in 12% The lack of correlation between serology and EMB remained also for patients with biopsy-proven myocarditis and patients with time from initial symptoms to EMB procedure of ≤1 month.For patients with suspected myocarditis, virus serology has no relevance for the diagnosis of myocardial infection. protein VP1 in myocardium from cases of myocarditis or dilated Search for other works by this author on: Signs and symptoms include chest pain, fatigue, shortness of b… The viral genome was detected in the myocardium by polymerase chain reaction. Acute viral infection with enterovirus, adenovirus, parvovirus B19, cytomegalovirus, human herpesvirus, and Epstein-Barr virus was diagnosed by IgM or IgA in the initial sample or IgG seroconversion in the follow-up sample.
A histopathologic definition and classificationMyocarditis and inflammatory cardiomyopathy: microbiological and molecular biological aspectsCoxsackievirus B epidemiology and public health concernsAntibody responses in parvovirus B19 infected patientsSeroprevalence of parvovirus B19 in the German populationSeroprevalence of herpes simplex virus type 2 among persons aged 14–49 years–United States, 2005–2008Effect of viral load on the outcome of herpes zosterA prospective case-control study of antibodies to coxsackie B virus in idiopathic dilated cardiomyopathyComplications of transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy: a seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral centerTechniques for right and left ventricular endomyocardial biopsyComplication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year periodComparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performanceDetection of viruses in myocardial tissues by polymerase chain reaction. Virus serology in patients with cardiomyopathy than in those without myocardial inflammation. Sophie Mavrogeni (with Pantelis Constantoulakis*, George Stavridis, K. Bratis, Genovefa Kolovou) Myocarditis is an inflammatory heart disease classified by clinical, immunohistological, and clinicopathological criteria and is usually caused by infectious agents.1,2 In Europe and North America, viral infections are the most common causes of myocarditis.3 The clinical picture of patients with myocarditis is highly variable, ranging from asymptomatic courses to severe illness with the necessity of intensive care therapy.4–6 The diagnosis of myocarditis is based on histopathological and immunohist… myocardium. Different viral or microbial genomes in EMB can be innocent by-standers in In quantitative assays such as the neutralization assay or the complement fixation reaction, a four-fold increase in titre between the initial and the follow-up samples or a significantly high titre (>1:256 in the neutralization assay or >1:80 in the complement fixation reaction) defined an acute infection.
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